Scientist – Protein Purification and Biochemistry

CK Group are recruiting for a Scientist – Protein Purification and Biochemistry to join a biotech start-up focused on developing novel immunotherapies.

The role will be based at their site in Cambridge and is a 1 year Fixed Term Contract role, with Mon-Fri day time working hours.

The Role

We are seeking an enthusiastic and motivated Scientist to join our team in Cambridge. Working with a dynamic group of drug discovery scientists, you will contribute to the therapeutic pipeline by applying expertise in protein purification and biochemistry. The successful candidate will support construct design, protein production, and biochemical characterization to help advance novel drug discovery programmes.

Responsibilities:

• Manage and coordinate recombinant protein expression and purification at CROs and/or in-house, ensuring protein quality and suitability for downstream assays.
• Developing innovative approaches to overcome complex protein production and purification challenges.
• Driving continuous improvement in protein delivery methodologies.
• Collaborating with cross-functional teams to support and deliver to key project objectives.
• Acting as a technical lead to establish science work plans with relevant outsourcing partners.
• Supporting the gap analysis and leading the initiative to identify new outsourcing partners to optimise delivery timelines and efficiencies.
• Work with CROs to ensure candidates meet therapeutic development criteria.

Your Background:

Essential:

• A minimum of a BSc Degree in Biochemistry, Molecular Biology, or related discipline
• Hands-on experience with protein purification techniques (Protein A, affinity chromatography, SEC)
• Experience working with matrices such as cell lysates and human serum
• Understanding of analytical techniques (SEC, SDS-PAGE, charge-based assays, mass spectrometry) applied to therapeutic proteins
• Understanding of SPR techniques applied to therapeutic antibodies
• Awareness of therapeutic antibody development considerations

Desirable:

• Experience coordinating protein expression and purification in CRO or in-house settings
• Experience with biochemical assays such as SPR and ELISA
• Familiarity with antibody optimization approaches
• Ability to run SPR experiments on therapeutic antibodies

Apply:

It is essential all applicants hold entitlement to work in the UK. Please quote job reference 153 477 in all correspondence.

INDLS