Senior Scientist - In Vitro Pharmacology
CK Group is seeking a dynamic scientist /senior scientist to join our client who are based in Waltham, MA on a full time basis.
The Company:
Our client are a growing clinical stage biopharmaceutical company, established to pioneer the next generation of therapies in the oncology and autoimmune space.
Job Summary:
The successful candidate will join an In vitro Pharmacology group to lead early-stage studies and programs with investigative drug candidates.
The ideal candidate will have a strong background in in-vitro and ex-vivo target validation and mechanism of action (MoA) interrogation across multiple cell types.
Responsibilities:
- Independently design and execute experiments and studies to evaluate performance of investigative drugs (biologics)
- Stay updated with cutting edge discoveries and trends and contribute to the company’s R&D strategy to generate and test actionable development plans
- Identify emerging methods, tools, and biology approaches, and implement them when applicable
- Function as a project and program leader and simultaneously mentor, train and supervise associates on the R&D team
- Collaborate closely with other scientists and research associates on the R&D team
- Contribute to work with external parties, including academic collaborators and CROs to create comprehensive capabilities for MoA, target validation and potency studies
- Write clear and concise research reports and ensure study documentation and update protocols toELN
- Participate and contribute to internal discussions and meetings
- Present results to the project leadership team and management in an organized and timely manner
Your Background:
- Ph.D. in Cellular Biology, Immunology, or a relevant discipline
- 3-5 years of related industry research experience (including post-doc)
- Extensive experience working with different types of in vitro systems such as immune cells, epithelial cells, fibroblasts, endothelial cells, and other cell lines- Strong background with cell based assays to interrogate immune pathway activation, immune suppression, cytotoxicity, antibody mediated cell killing
- Broad skillset for target validation, potency evaluation and MoA interrogations is highly desired, including the use of tissue culture approach with multiple readouts, flow cytometry, ex-vivo studies, use of gene knockdown tools, conventional immunoassays, phosphorylation analysis and conventional pulldown assays
Benefits:
Competitive salary, plus bonus and health plans
Apply:
For more information please contact Hannah Oakley or Rob Angrave on +1 (617) 6922948. Please quote job reference 54215 in all correspondence.
It is essential that you have full rights to work in the US.